After Girl Crazy closed, Ginger moved on to Hollywood. Nineteen films into her career she joined Fred Astaire at RKO Radio Studios in Flying Down to Rio. The new team took the world by storm, subsequently making eight more pictures together at RKO: Gay Divorcee, Roberta, Top Hat, Follow the Fleet, Swing Time, Shall We Dance, Carefree and The Story of Vernon and Irene Castle. Ten years later they made their 10th film together for MGM, The Barkleys of Broadway.
Garson Kanin wrote of them, "The magic of Astaire and Rogers cannot be explained; it can only be felt. They created a style, a mood, a happening. They flirted, chased, courted, slid, caressed, hopped, skipped, jumped, bent, swayed, clasped, wafted, undulated, nestled, leapt, quivered, glided, spun - in sum, made love before our eyes. We have not seen their like since."